I use red label almost exclusively. On baitcasters I don't worry about it. On spinning gear I will stretch the line and remove the twist that is inherently introduced into the reel after a ton of hours / days fishing with it.
Later,
Geo
Funny thing is I wouldn't even be using Flouro if you hadn't mentioned the knot being the problem on me breaking off all the time. Now I use it on everything except my top water rod and spinning reels. It's great stuff.