I would do the lower end of the lake for smallmouth. As for striper I know very little about them and I rarely target them to fish but when they are present I have caught a few. I don't know how dead set you are on the May time frame but anytime you get two decent days of warm temperatures back to back in March the Cumberland smallmouth bite can be great. The key word in that last sentence was warm. Clear, sunny, bluebird highs are good anytime in early spring to help warm the water but a good cloudy warm front with a light warm rain is a perfect storm for hot action. The problem is in March it can be 20* and snowing one day and 65* and nice the very next day. May will be a little more stable weather wise but if you pay close attention to the the forecast and find a 2-3 day window that looks good then March would be my choice for smallmouth.
Right now I am scheduled off the last two weeks in March for vacation. If the weather is right I may add some more vacation or sick time and take the last three weeks in March off. I do this every year. I use to do it in April but I have found that March is better for big fish but the weather can throw a curve ball. I am only about 30 minutes from Cumberland so I can easily make a last minute decision to go or stay at home. I spend my time on Cumberland and Green in late winter/early spring and switch to just Green once the bass spawn is in full swing.
Now if my memory is correct (and the striper fishermen will know) the night striper bite heats up in May (mid/late?) when the shad spawn is going on. I "think" its more towards the end of May. Anyways I do recall about 5-6 years ago taking the only trip I have ever went where striper was the target. I went with a friend and we targeted steep shale banks at night where the shad spawn was going on. It was actually more like hunting than fishing. We would run to an area and shut down the boat 100 yards or more away from where we though a bank would be a good bank for shad to spawn on and listen. If stripers were feeding on shad on the bank it would sound like someone threw a brick overboard. We would be as quite as possible and ease into the area with topwater plugs. If nothing was present we would sometimes ease down a bank just blind casting but we always were listening for a blow up. It was a blast and I tell my self every year that I am going back to try it but I have only done it once. Whenever and wherever you decide to go I wish you luck.



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Thanks to all of you for your input