I'm right handed and have always used left handed baitcasters. I cast with my right and reel with the left. No hand changes. This lets me cast and set the hook with my more coordinated arm/hand and never switch hands after casting. I can turn the handle, lock the reel and set the hook (in case of a fast strike) while others are switching hands. Often I'm ready to set the hook before or at the same time the lure enters the water. Its seem more natural to me. If your right handed you can definately react to a strike faster and harder with the rod in your right hand. Many pros have taught themselves to use left handed reels because of all the advantages. But if you are used to a right handed reel it will take awhile to adjust. Some pro's use both hands for different types of fishing.