If you want it to run to it's desired depth 10 lbs. is as big as you should go. I know some of the pro's around here use less than 10 on the deeper diving crankbaits. It is not the rate that it sinks, however the resistance created as the line cuts through the water when it is running. The smaller the diameter of the line, the less resistance it will have traveling through the water.
There are some benifits of both flouro and mono for cranking. Flouro is going to have a slightly smaller diameter for the same pound test when compared to most mono's. However, mono has a little more stretch than flouro, which could help if you have a problem of yanking on the rod before the fish gets it's mouth around the crankbait.
A rod with a soft, slow tip is just as important as line selection when fishing crankbaits - more for landing a fish, than how the lure runs.



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