I use 10/2 PowerPro on spinning gear, throwing 1/32-1/16oz jigs. Wind knots can be a problem ... but, are most likely to occur if you "snap cast" (fast, wrist type of cast). If you cast overhand or sidearm, try casting with more of a smoother action ... or lob ... to your cast.
Lures will spin, light jigs especially, when cast ... so you may ocasionally have to remove the lure and drag the empty line behind the boat (idle speed areas are good places for this) to remove some of the twist. (I do the same for mono !!)

... cp