Vanish does not work with a palomer knot it breaks every time. If you use a trilene knot it does hold 10 times better than the palomer knot. I myself stop using vanish a long time ago and started using Pline or Seugar but before I threw the Vanish away I tried different knots and trilene does hold. I certainly would not switch back but if you still have Vanish try tying a different knot it makes a big difference for some reason on that line.