My favorite all around line is Gamma Copolymer. Super strong, casts excellent, and extrememly durable.

On a very few set-ups, I use Flouro, and Seagar Invis-X is my favorite there. If I were fishing very clear lakes, or alot of deep water jigging, I would use Flouro more often - but here on Ky lake, the water never gets clear enough to really see the benefits of flouro. I do like it's sensitivity, but can really tell a noticeable difference on deeper jigging. I used to use all flouro, but it's biggest drawback is if there is the smallest knick in the line, it is has zero strenght. I fish alot of rocky areas here, and it can shred some line - so now I only use it on deeper (over 20 feet) jigs, and finnesse stuff.