I agree that Insurance should be a big part of any decision when it comes to employment. Dang stuff amounts to a monthly car payment or house payment in some cases.
I have had to make this decision myself and what I did was step away from it so I could get my mind right and ask myself a few questions. I was really being pushed to be a business owner by several contractors.

1) What is it I really want out of life? Riches? Live comfortable and be happy?
2) Am I happy now?
3) Where will I be in 10 years in either job?
4) What kind of a safety net (financial) will I need for the lean months?
5) Knowing myself...can I really handle dealing with losers out there who don't pay?
6) My health gonna suffer?

This is how I looked at it with other questions as well but you get the idea and each situation is different but I chose not to go in business and man what a good decision that was since the economy status would have hurt me.
Good luck and all I can say is to pray on it and the answer will be there.