I make that run all the time. I-65S out of Louisville to the West KY Parkway and stay on it until it ends, go I-24 west, then take exit 31 (Grand Rivers exit) and go south and it will turn into The Trace which is the main road through LBL
It's the fast way to get there without taking a bunch of backroads, etc. I can leave Louisville, set the cruise, and never have to hit the brake until exit 31. Takes about 2.5 hours. I'll be heading that way for the Labor Day weekend to camp in Smith Bay.
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