The upper dam (McAlpine) is good when the flow is right...usually 1 or 2 gates opened about halfway when the river is up a foot or so. Stay about 50 yds from the dam face and cast into any current seams you can reach. Have had excellent luck using pink grubs on a 1/4 oz jighead.

Two options on the lower end. 1) Work the banks around the two Clarksville ramps with sabikis, road runners, or jig/grub combos. 2) Walk down from the visitors center for the locks to the face of the lower dam. I've been told that it is a pretty long hike though. I believe the lock visitor center is accessed from the new little bridge across the locks built near downtown Louisville.