I personnally like line conditioners on braid and mono, but I especiallly like it on fluoro. I use the KVD stuff and it works great. I like braid with a fluoro leader for many presentations and tie (the leader) with a double uni durring the day and a surgeons knot at night as it is easy to "feel". Even if you dont use line conditioner, braid with fluoro leader wont have much if any line twist issues. I take my all fluoro rigs and tie them to something at the house and stretch (just a little) and always put line conditioner on the night before.